Pistorius cries in court as slain girlfriend is laid to rest

Oscar Pistorius is pictured with Reeva Steenkamp in Johannesburg, South Africa, in January.

STORY HIGHLIGHTS

• NEW: Pistorius' defense says he shot his girlfriend thinking she was a burglar


• A prosecutor asks why a burglar would lock up in a bathroom


• The funeral for Steenkamp will take place Tuesday


• Pistorius, known as the "Blade Runner," is in court for a bail hearing

Pretoria, South Africa (CNN) -- Oscar Pistorius sobbed uncontrollably in a Pretoria courtroom Tuesday as prosecutors described how they say he murdered his girlfriend.

The state said the killing was premeditated: Pistorius armed himself, attached his prosthetic legs and walked 7 meters before shooting Reeva Steenkamp, who had come to spend the night, through the bathroom door, prosecutors said.

Pistorius fired four times, prosecutors said; Steenkamp was struck thrice inside a locked bathroom.

He "shot and killed an innocent woman," senior state prosecutor Gerrie Nel said.

As Nel spoke, Pistorius buried his face in his hands.

But defense attorney Barry Roux said the shooting was not premeditated; Pistorius shot his girlfriend thinking she was a burglar, he said.

The prosecution doubted that assertion, asking why a burglar would lock up in a bathroom.

But Roux questioned how the prosecution would know Pistorius attached his prosthetic legs and walked to the bathroom. Police have said Pistorius and Steenkamp, now deceased, were the only ones in the home.

The global sports hero, known as the "Blade Runner," was in court for a bail hearing Tuesday. The last time the world saw images of Pistorius was when he was initially charged Friday, when the track star crumbled upon hearing the word "murder."

The courtroom scenes are a far cry from the packed stadiums that erupted in applause for the double-amputee who dared to compete against men with legs.

Police have released little about a possible motive in the Valentine's Day shooting of his girlfriend.

Items found in Pistorius' home suggest Steenkamp intended to stay the night. She had an overnight bag and her iPad, a South African official familiar with a case said Monday.

The 29-year-old model was alive after she was shot, and Pistorius carried her wounded body downstairs, said the official, who was not authorized to release details to the media.

Police were alerted to the shooting by neighbors, and residents had "heard things earlier," spokeswoman Denise Beukes said.

A police spokeswoman said there had been "previous incidents" at the home, including "allegations of a domestic nature." They did not detail what those may been.

Detectives are investigating a blood-stained cricket bat in the home, Johannesburg's City Press newspaper reported, and are trying to determine whether it was used to attack Steenkamp, if she used the bat in self-defense, or if Pistorius used it to try to break down the bathroom door.

Pistorius, 26, has rejected the murder allegation "in the strongest terms," his agent said in a statement.

As the drama in court unfolds, friends and family will mourn Steenkamp at a private funeral service in her hometown of Port Elizabeth.

On Sunday, South Africans heard Steenkamp's voice one last time after her death, when the national broadcaster aired a pre-recorded reality TV show featuring the model discussing her exit from "Tropika Island of Treasure," on which local celebrities compete for prize money.

"I'm going to miss you all so much and I love you very, very much," she said, blowing a kiss to the camera.

Robyn Curnow reported from South Africa; Holly Yan reported and wrote from Atlanta. CNN's Nkepile Mabuse also contributed to this report.

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WH: Leaked immigration plan is only partial draft

(CBS News) WASHINGTON -- Over the weekend, a partial White House plan for immigration reform leaked to the press and caused an uproar.

White House officials tell CBS News that what was leaked is real -- it's a partial draft of half a bill. What we know is the administration's current thinking about what to do about the estimated 11 million illegal immigrants living in the United States right now.

The administration wants a temporary four-year visa to provide legal status -- meaning no more deportations -- that could be renewed. After eight years, they can apply for what's known as permanent legal residency, or, more commonly, a Green Card.

(At left, watch White House Chief of Staff Denis McDonough discuss the leaked immigration plan on "Face the Nation.")

There's also administration thinking on border security and an unspecified increase in border security, subject to negotiations with Congress. For workers who try to find jobs in the future and who might not have documents, the plan includes an E-Verify system to make sure undocumented workers aren't given jobs.

GOP: Leaked WH immigration plan "counterproductive"
W.H. immigration plan circulating in case Congress talks "break down," McDonough says

What's missing is a section dealing with all future legal immigration issues: high-skilled workers, seasonal farm workers and workers who work in hotels or restaurants. Without that, this plan doesn't have much of a chance.

The plan is not likely to get through Congress without the section dealing with legal immigration. That's why Republicans were so critical this weekend.

Last year, Republicans criticized the president for being missing in action and failing to draft a bill. Now that he admits he is, Republicans say he's contaminating that process; they argue that if you don't have a comprehensive bill -- one that can pass Republicans and Democrats in both the House and Senate -- this is a futile effort.

The White House says Republicans are going to be dared to vote up or down eventually, and that they better get used to that.

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Russian Meteor: Close Encounter, Preventing Impacts

Feb 18, 2013 7:03pm

MOSCOW — As if Friday’s massive meteor explosion over central Russia weren’t enough, just hours later a large asteroid buzzed dangerously close to Earth.

And that evening, the California sky was lit up by a fireball, apparently entering Earth’s atmosphere.

It’s a barrage from space that has people asking: Are we ready for the big one?

Nearly 100 tons of space debris enters Earth’s atmosphere every day. Most of it burns up or falls harmlessly into the ocean, but experts still worry that eventually something big will come our way.

PHOTOS: Meteorite Crashes in Russia

Image credit: Chelyabinsk Region Branch of Russian Interior Ministry/HO/EPA

The prospect of Earth getting hit by a giant hunk of space rock is concerning enough that the United Nations is gathering top minds in Italy this week to discuss it.

Scientists say the idea of blowing up an asteroid — as Bruce Willis’ character did in the movie “Armageddon” — is pure Hollywood fantasy. Even if we could hit it, it’s unlikely to stop it.

Existing sky-watching programs run by NASA and others can only spot the biggest asteroids, not the small ones that sneak up on us.

But fear not, citizens of Earth. Scientists have a plan.

RELATED: Russian Meteor: Rushing to Cash in on the Blast

One group, the non-profit B612 Foundation, proposes sending a telescope, called Sentinel, into space to detect incoming objects decades before their orbits intersect ours. Then, unmanned spacecraft could fly to them and nudge them clear of Earth’s path.

The group is trying to raise $200 million to make it happen and hopes to launch the telescope by 2016.

Another project, proposed by the University of Hawaii, aims to give earthlings a heads-up when necessary, starting by 2015.

RELATED: Meteor Events: Rare, but Dangerous

It is called the Atlas program, and the plan is to deploy a string of telescopes that would search for even smaller objects in the sky, hoping to be able to give people at least a few day’s notice that could allow time for an evacuation.

Until then, better keep Bruce Willis on speed dial.

SHOWS: World News

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Nuclear waste: too hot to handle?

Cumbria's decision to veto an underground repository for the UK shows how hard it is to find a long-term solution

THERE are 437 nuclear power reactors in 31 countries around the world. The number of repositories for high-level radioactive waste? Zero. The typical lifespan of a nuclear power plant is 60 years. The waste from nuclear power is dangerous for up to one million years. Clearly, the waste problem is not going to go away any time soon.

In fact, it is going to get a lot worse. The World Nuclear Association says that http://www.world-nuclear.org/info/inf102.html 45 countries without nuclear power are giving it serious consideration. Several others, including China, South Korea and India, are planning to massively expand their existing programmes. Meanwhile, dealing with the waste from nuclear energy can be put off for another day, decade or century.

It's not that we haven't tried. By the 1970s, countries that produced nuclear power were promising that repositories would be built hundreds of metres underground to permanently isolate the waste. Small groups of technical experts and government officials laboured behind closed doors to identify potential sites. The results - produced with almost no public consultation - were disastrous.

In 1976, West German politicians unilaterally selected a site near the village of Gorleben on the East German border for a repository, fuelling a boisterous anti-nuclear movement that seems to have no end in sight.

In the UK, the practice of choosing candidate sites with little public input was lampooned as "decide, announce, defend". In the US, backroom political manoeuvring led to the 1987 selection of Yucca Mountain in Nevada, at the time an under-populated gambling Mecca with no political muscle. Nevadans have been fighting what they call the "Screw Nevada Bill" ever since. The Obama administration pulled funding from Yucca Mountain to appease Senate majority leader Harry Reid, who is from Nevada, but the decision is still being battled in the courts and Congress, and the site is not completely off the table.

It took a while, but governments began to catch on that the top-down approach wasn't working. Time for a new strategy: look for a community willing to host a repository, using lots of touchy-feely language such as consent-based, transparent, adaptive, phased and terminable. On paper, it is win-win. Sweden and Finland, those paragons of Nordic cooperation and efficiency, are now in the home stretch for opening the world's first nuclear waste repositories, and are held up as proof-positive that the new policy can work.

Yet finding a volunteer community is the relatively easy part, because nuclear waste repositories bring jobs and money. But this doesn't mean their neighbours, or the regional powers that be, are going to go along with it.

This unfortunate aspect of policymaking became readily apparent in the UK last month. Everything seemed a sure shot for taking the next exploratory steps toward a nuclear waste repository in west Cumbria. Located next door to Sellafield, the granddaddy of the UK's nuclear facilities, two local communities comfortable with nuclear matters were in favour. The bugles and bunting were practically being unfurled when Cumbria County Council, concerned about tourism in the Lake District and possible future leaks, vetoed the plan. No other volunteers are in line as a backup.

The US recently announced its own volunteer-based policy, including promises to have an interim storage site up and running within eight years and a repository by 2048. It should know better. Is it forgetting its own track record, even with interim storage facilities?

In the 1980s, the community of Oak Ridge, Tennessee, agreed to host an interim facility. Statewide opposition shut it down. In the 1990s, the Skull Valley Band Of The Goshute Nation, a recognised Native American sovereign nation, volunteered to host an interim facility on its reservation in Utah. Last December, after more than 15 years of legal sparring with the state, the utilities working with the Goshute finally gave up.

The most recent volunteer community to be snubbed is Nye County, where Yucca Mountain is situated. After a commission chartered by the Obama administration recommended a new "consent-based" approach to break the deadlock over the site, Nye County officials wrote to US energy secretary Steven Chu giving their consent to host the repository at Yucca Mountain. Nevada Governor Brian Sandoval subsequently informed Chu that the state of Nevada will never consent to a repository.

It's now over half a century since the dawn of nuclear energy and dangerous and long-lived waste continues to pile up all over the globe. Something needs to be done. Although touted as the solution, finding a consenting community is merely the first step. The harder part is getting everyone else to sign on.

And then comes the real challenge - to determine if the ground beneath a volunteer community is geologically suitable for a repository. This daunting endeavour requires a decades-long process that is both politically sensitive and technically complex. Inevitably, surprises occur as studies go underground. Here, the public needs an independent, technically savvy group whom they trust to address their concerns and interpret the scientific results.

The difficulties of finding a happily-ever-after triad of volunteer community, consenting neighbours and geologically suitable site cannot be lightly dismissed. Replacing a top-down approach with a consent-based one is a step in the right direction, but it doesn't fundamentally solve the problem.

This article appeared in print under the headline "Down in the dumps"

William M. Alley oversaw the US Geological Survey's Yucca Mountain project from 2002 to 2010

Rosemarie Alley and William M. Alley are authors of Too Hot To Touch: The problem of high-level nuclear waste (Cambridge University Press)

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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Hong Kong Disneyland turns a profit for first time

HONG KONG - Hong Kong's struggling Disneyland in 2012 made a profit for the first time since opening eight years ago, thanks to a surge in revenue as it welcomed a record number of visitors.

The park made HK$109 million ($14.06 million) in the fiscal year ending September 29, 2012, compared with a net loss of HK$237 million the year before.

The result was fuelled by a 13 per cent jump in attendance to a record 6.73 million people, providing relief for the resort, which has been battling lower-than-expected numbers since opening in 2005.

Visits by Hong Kong residents posted a record growth of 21 per cent while visits by mainland visitors expanded by 13 per cent. Revenue meanwhile grew 18 per cent to HK$4.27 billion.

Hong Kong Disneyland Resort's managing director Andrew Kam said it was "very encouraging" to see the "significant improvement".

He added: "Attendance, hotel occupancy and guest spending levels continued to reach all-time highs."

Hong Kong Disneyland, which is majority owned by the city's government, has been desperate to ramp up the number and quality of its attractions as it seeks to lure more visitors while facing stiff competition from local rival Ocean Park.

Critics have attributed many of its problems to its size -- it is the smallest of all the Disney's theme parks -- and a lack of attractions catered to the key China market, which accounts for nearly half of its visitors.

Doubts about the park's future have further been stoked since China gave approval for a park to be built in Shanghai.

A deal to open Hong Kong Disneyland was signed in 1999 as part of a plan to boost the city's economy as it reeled from the Asian financial crisis.

- AFP/ck

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Pope delivers one of his final messages

By Hada Messia and Josh Levs, CNN

updated 7:21 PM EST, Sun February 17, 2013

Pope Benedict XVI waves as he arrives to lead the Angelus prayer at the Vatican on Sunday.

STORY HIGHLIGHTS

• It's the pope's second-to-last Angelus prayer as pontiff


• Pope Benedict XVI thanks his flock for prayers and support


• He discusses "decisive moments of our lives"


• Cardinals may meet before March 15

(CNN) -- Pope Benedict XVI led tens of thousands in a prayer for strength Sunday and thanked followers for their support during his second-to-last Angelus prayer as pontiff.

"Today we contemplate Christ in the desert, fasting, praying, and being tempted," the pope said to an unusually large crowd at St. Peter's Square in Vatican City.

"As we begin our Lenten journey, we join him and we ask him to give us strength to fight our weaknesses. Let me also thank you for the prayers and support you have shown me in these days. May God bless all of you!"

Benedict, 85, shocked millions across the world last week when he announced his intention to stand down at the end of the month, citing the frailty of old age.

The decision makes him the first pope to step down in nearly 600 years.

Referring Sunday to a Bible passage, the pope said, "During the decisive moments of our lives, and in fact at every moment, we are in front of a crossroads: Do we want to follow the I or God? The individual interest or the true good, that which really is the good?"

The crowd appeared to have about 100,000 people

He also tweeted a message to followers worldwide, calling on them to "rediscover faith" as a foundation.

Cardinals may meet before March 15 to choose the next pope if they are all in Rome, a Vatican spokesman said Saturday. The conclave will bring together the 117 cardinals of the Roman Catholic Church.

Part of complete coverage on

What do you think about the Pope's decision to resign? If you are a Catholic, how will it affect you? Send us your thoughts and recollections.

Read all of the latest updates, including standards for the next pope and possible successors on CNN's Belief Blog.

They are the largest group in the Roman Catholic Church, and the next pope might even come from their midst. Yet few have heard how Latino Catholics regard the legacy of Pope Benedict XVI.

updated 11:07 AM EST, Tue February 12, 2013

Before he was Pope Benedict XVI, before he earned the nickname "Cardinal No" as the enforcer of church doctrine, he was Joseph Ratzinger.

The news stunned both the Church's 1.2 billion followers and the rest of the world. Here's a collection of your views from social media.

updated 11:02 AM EST, Tue February 12, 2013

Pope Benedict XVI's decision to resign caught a lot of Vatican watchers, apparently even some in his inner circle, off-guard. They should not have been so surprised.

updated 9:36 AM EST, Mon February 11, 2013

Pope Benedict's German background has always been a talking point. CNN's Fred Pletigen takes a look at Pope's German roots.

updated 7:27 PM EST, Mon February 11, 2013

Pope Benedict XVI on Monday said he plans on resigning the papal office on February 28. Click here for the full text of Benedict's declaration.

updated 12:30 PM EST, Mon February 11, 2013

Assuming Pope Benedict XVI steps down as planned at the end of February, his tenure on Twitter will have been fleeting.

updated 6:26 AM EST, Tue February 12, 2013

After his resignation, Benedict, 85, will probably retire to a monastery and devote himself to a life of prayer. Look back at his time as Pope.

updated 2:12 PM EST, Mon February 11, 2013

The surprising news from Rome, Monday, leaves the church and the world in unfamiliar, but not entirely uncharted, territory.

updated 9:13 AM EST, Mon February 11, 2013

Pope Benedict directed the church's response to decades of abuse by its priests. CNN's Nic Robertson reports.

updated 11:06 AM EST, Tue February 12, 2013

We explore what the surprise announcement means for the Catholic Church.

updated 8:58 AM EST, Mon February 11, 2013

CNN's Jim Bittermann looks at the legacy and controversies that have marked Pope Benedict XVI's reign.

updated 10:56 AM EST, Fri November 23, 2012

A book released by Pope Benedict XVI last year looks at the early life of Jesus -- and debunks several myths about how the Nativity unfolded.

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Danica Patrick makes NASCAR history

DAYTONA BEACH, Fla. Danica Patrick has made history before — as a woman and a racer, in Indianapolis and Japan.

The spotlight is nothing new. But never has it been this bright before.

Patrick won the Daytona 500 pole Sunday, becoming the first woman to secure the top spot for any race in NASCAR's premier circuit. It's by far the biggest achievement of her stock-car career.

29 Photos

Danica Patrick

"I was brought up to be the fastest driver, not the fastest girl," she said. "That was instilled in me from very young, from the beginning. Then I feel like thriving in those moments, where the pressure's on, has also been a help for me. I also feel like I've been lucky in my career to be with good teams and have good people around me. I don't think any of it would have been possible without that.

"For those reasons, I've been lucky enough to make history, be the first woman to do many things. I really just hope that I don't stop doing that. We have a lot more history to make. We are excited to do it."

Her latest stamp in the history books came with a lap at 196.434 mph around Daytona International Speedway. Patrick went out eighth in the qualifying session, then had to wait about two hours as 37 fellow drivers tried to take her spot.

Only four-time Cup champion Jeff Gordon even came close to knocking her off. Gordon was the only other driver who topped 196 mph in qualifying. He locked up the other guaranteed spot in next week's season-opening Daytona 500.

"It's great to be a part of history with Danica being on the pole," said Gordon, who joked that at least he was the fastest guy. "I think we all know how popular she is, what this will do for our sport. Congratulations to her. Proud to be on there with her."

• Danica Patrick crashes in Daytona qualifier

The rest of the field will be set in duel qualifying races Thursday.

However the lineup unfolds, all drivers will line up behind Patrick's No. 10 Chevrolet SS.

And she knows her latest achievement will mean more public relations work.

The routine is nothing new for Patrick, who was the first woman to lead laps in the Indianapolis 500. She finished third in 2009, the highest finish in that illustrious race for a woman. And she became the only woman to win an IndyCar race when she did it in Japan in 2008.

Hardly anyone witnessed that victory.

Leading the field to the green flag in NASCAR's showcase event should be must-watch television.

"That's a huge accomplishment," team owner and fellow driver Tony Stewart said. "It's not like it's been 15 or 20 years she's been trying to do this. It's her second trip to Daytona here in a Cup car. She's made history in the sport. That's stuff that we're proud of being a part of with her. It's something she should have a huge amount of pride in.

"It's never been done. There's only one person that can be the first to do anything. Doesn't matter how many do it after you do, accomplish that same goal. The first one that does always has that little bit more significance to it because you were the first."

Even before her fast lap Sunday, Patrick was the talk of Speedweeks. Not only did she open up about her budding romance with fellow Sprint Cup rookie Ricky Stenhouse Jr., but she was considered the front-runner for the pole after leading practice sessions Saturday.

And she didn't disappoint.

She kept her car at or near the bottom of the famed track and gained ground on the straightaways, showing lots of power from a Hendrick Motorsports engine.

"It's easy to come down here in your first or second year as a driver and clip the apron trying to run too tight a line or do something and scrub speed off," Stewart said. "That's something she did an awesome job. Watching her lap, she runs so smooth. ... She did her job behind the wheel, for sure."

The result surely felt good for Patrick, especially considering the former IndyCar driver has mostly struggled in three NASCAR seasons. Her best finish in 10 Cup races is 17th, and she has one top-five in 58 starts in the second-tier Nationwide Series.

She raced part-time in 2010 and 2011 while still driving a full IndyCar slate. She switched solely to stock cars last season and finished 10th in the Nationwide standings.

She made the jump to Sprint Cup this season and will battle Stenhouse for Rookie of the Year honors.

Starting out front in an unpredictable, 500-mile race doesn't guarantee any sort of result, but securing the pole will put her in the limelight for at least the rest of the week.

She also won the pole at Daytona for last year's Nationwide race.

This is considerably bigger.

The previous highest female qualifier in a Cup race was Janet Guthrie. She started ninth at Bristol and Talladega in 1977.

"It's obviously a history-making event that will last a long, long time," Guthrie said, praising Patrick's feat. "It's a different era, of course. Different times. I can't imagine what I would do with a spotter or somebody telling me how to drive. It's rather a different sport now. Back then, there was a much greater difference from the front of the field to the back."

Guthrie received a lukewarm reception from fellow drivers back then.

Patrick was much more welcomed, undoubtedly because of her background and popularity.

She's comfortable being in the spotlight, evidenced by her racing career, her television commercials and her sudden openness about her personal life.

"I think when pressure's on and when the spotlight's on, I feel like it ultimately ends up becoming some of my better moments and my better races and better results," Patrick said. "I just understand that if you put the hard work in before you go out there that you can have a little peace and a little peace of mind knowing that you've done everything you can and just let it happen."

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Country Star Mindy McCready Shot Herself, Cops Say

Mindy McCready, the country singer who soared to the top of the charts with her debut album, "Ten Thousand Angels," but struggled with substance abuse, served time in jail and fought a lengthy battle with her mother over custody of her son has died of what appears to be a self-inflicted gunshot wound, police said. She was 37.

Deputies from the Cleburne County Sheriff's Office were dispatched to a report of gun shots fired at McCready's Heber Springs, Ark., home at around 3:30 p.m. today.

There they found McCready on the front porch. She was pronounced dead at the scene from what appeared to be a single self-inflicted gunshot wound, according to a statement from the sheriff's office.

McCready's boyfriend, David Wilson, died in January of a self-inflicted gunshot wound. McCready was ordered to enter rehab shortly after Wilson's death, and her two children, Zander, 6, and 9-month-old Zayne were taken from her. She was released after one day to undergo outpatient care.

McCready scored a number-one Billboard country hit in 1996 with "Guys Do It All the Time," but in recent years, the country crooner has received more media attention for her troubled personal life than her music.

She has been arrested multiple times on drug charges and probation violations and has been hospitalized for overdoses several times, including in 2010, when she was found unconscious at her mother's home after taking a painkiller and muscle relaxant.

Angela Weiss/Getty Images

Her mother, Gayle Inge, was appointed to be her son Zander's legal guardian in 2007 after McCready was arrested for violating probation on a drug-related charge. The boy's father is McCready's ex-boyfriend Billy McKnight.

Following a custody hearing in May 2011, McCready released a statement, saying, "We have progressed in a positive manner to reunite me and my son, Zander. I feel very optimistic this will happen in the near future."

But just six months later, in November 2011, was accused of violating a court order for failing to bring Zander back to her mother in Florida after a visit. The boy was placed in foster care while McCready and her mother worked out the custody dispute.

McCready's struggle with substance abuse was broadcast in 2010 on the third season of "Celebrity Rehab with Dr. Drew."

McCready also claimed to have carried on a decade-long affair with baseball star Roger Clemens that began was she was 15 years old and he was 28. Clemens denied that the relationship was sexual in nature.

"You know what, I don't think I'm ever going to be one of those people that has a normal, quiet existence," McCready told ABC Radio in 2010. "I've been chosen for some reason to be bigger and larger than life in every way. Negative and positive."

McCready, who was born and raised in southern Florida, moved to Nashville when she was 18 to start her music career.

Within a few months, she was starting to work with producer David Malloy, who got her tapes to RLG Records. The company signed her to a contract after seeing her in concert, giving her a record deal less than a year after her arrival in Nashville.

Her debut album, "Ten Thousand Angels," went gold within six months of its release in April 1996, and eventually went multi-platinum. Two more followed: "If I Don't Stay the Night," in 1997; and "I'm Not So Tough" in 1999.

Her most recent album, "I'm Still Here," featuring new versions of her early hits "Ten Thousand Angels" and "Guys Do It All the Time," was released in March 2010.

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False memories prime immune system for future attacks

IN A police line-up, a falsely remembered face is a big problem. But for the body's police force – the immune system – false memories could be a crucial weapon.

When a new bacterium or virus invades the body, the immune system mounts an attack by sending in white blood cells called T-cells that are tailored to the molecular structure of that invader. Defeating the infection can take several weeks. However, once victorious, some T-cells stick around, turning into memory cells that remember the invader, reducing the time taken to kill it the next time it turns up.

Conventional thinking has it that memory cells for a particular microbe only form in response to an infection. "The dogma is that you need to be exposed," says Mark Davis of Stanford University in California, but now he and his colleagues have shown that this is not always the case.

The team took 26 samples from the Stanford Blood Center. All 26 people had been screened for diseases and had never been infected with HIV, herpes simplex virus or cytomegalovirus. Despite this, Davis's team found that all the samples contained T-cells tailored to these viruses, and an average of 50 per cent of these cells were memory cells.

The idea that T-cells don't need to be exposed to the pathogen "is paradigm shifting," says Philip Ashton-Rickardt of Imperial College London, who was not involved in the study. "Not only do they have capacity to remember, they seem to have seen a virus when they haven't."

So how are these false memories created? To a T-cell, each virus is "just a collection of peptides", says Davis. And so different microbes could have structures that are similar enough to confuse the T-cells.

To test this idea, the researchers vaccinated two people with an H1N1 strain of influenza and found that this also stimulated the T-cells to react to two bacteria with a similar peptide structure. Exposing the samples from the blood bank to peptide sequences from certain gut and soil bacteria and a species of ocean algae resulted in an immune response to HIV (Immunology, doi.org/kgg).

The finding could explain why vaccinating children against measles seems to improve mortality rates from other diseases. It also raises the possibility of creating a database of cross-reactive microbes to find new vaccination strategies. "We need to start exploring case by case," says Davis.

"You could find innocuous pathogens that are good at vaccinating against nasty ones," says Ashton-Rickardt. The idea of cross-reactivity is as old as immunology, he says. But he is excited about the potential for finding unexpected correlations. "Who could have predicted that HIV was related to an ocean algae?" he says. "No one's going to make that up!"

This article appeared in print under the headline "False memories prime our defences"

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Pakistani city mourns after bomb kills 81

QUETTA, Pakistan: The death toll from a devastating bomb attack on Shiite Muslims in southwest Pakistan rose to 81 on Sunday, as the community threatened protests if swift action was not taken against the killers.

The bomb containing nearly a tonne of explosives, hidden in a water tanker, tore through a crowded market in Hazara town, a Shiite-dominated area on the edge of Quetta, the capital of Baluchistan province, early on Saturday evening.

The death toll from the blast, which demolished a nearby two-storey building, rose to 81 overnight, senior police official Wazir Khan Nasir told AFP, while 178 people were wounded.

Baluchistan has increasingly become a flashpoint for the surging sectarian violence between Pakistan's majority Sunni Muslims and Shiites, who account for around a fifth of the country's 180 million people.

Saturday's attack takes the death toll in sectarian attacks in Pakistan this year to almost 200, compared with more than 400 in the whole of 2012 -- a year which Human Rights Watch described as the deadliest on record for the country's Shiites.

It was the second major attack on Shiites in Quetta this year, after a double suicide bombing on a snooker club in the city on January 10 killed at least 92 people, the deadliest ever attack on the community in Pakistan.

Protests in the wake of the snooker hall attack prompted Islamabad to sack the provincial government and suspend its legislature and Shiite leaders said there would be more demonstrations if the culprits behind the market bombing were not caught.

Azizullah Hazara, chairman of the Hazara Democratic Party, Sunday gave a 48-hour deadline to the provincial government to launch targeted operations against the killers or they would launch protests.

Provincial home secretary Akbar Hussain Durrani said the dead and injured included women and children, and confirmed all the people trapped under rubble at the site of the collapsed building had been removed.

Durrani said that after clearance from doctors some 25-30 seriously wounded people would be airlifted to Karachi.

The chairman of the Shia Conference, Daud Agha, put the death toll at 83 and 194 wounded.

"Today a special mourning ceremony for the martyrs of last month's attack was already planned. We will announce the future course of action and time for burials after that in the afternoon," Agha told AFP.

The banned militant group Lashkar-e-Jhangvi (LeJ) claimed responsibility for Saturday's attack -- as it did for the snooker hall bombing and a February 1 attack on a Shiite mosque in northwest Pakistan that killed 24.

There is anger and frustration among Shiites at the apparent inability or unwillingness of the authorities to tackle LeJ. Activists say the failure of the judiciary to prosecute sectarian killers allows them to operate with impunity.

Sayed Qamar Haider Zaidi, a spokesman for Shiite groups in the area, condemned the Pakistani government for not providing protection to the community and announced three days of mourning and protest over the attack.

A large number of people gathered outside shops destroyed in the bombing and shopkeepers sifted through the debris to salvage any usable items on Sunday, an AFP photographer at the scene said, adding that people wept as they found human flesh and pieces of limbs.

Pakistan's national flag was flying at half mast after the provincial government declared a day of mourning over the killings and markets were closed.

Baluchistan, which borders Iran and Afghanistan, also suffers Islamist militancy and a regional insurgency which began in 2004, with rebels demanding political autonomy and a greater share of profits from the region's natural resources.

- AFP/xq

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